The purpose of this study is to determine whether fluid or glucose administration before hip replacement surgery minimizes postoperative muscle breakdown (catabolism), fatigue and disturbances in carbohydrate metabolism.
1. How can a simple and safe way to measure the body's tendency to transient diabetes associated with surgery? 2. Can fluid or glucose administration before elective hip surgery, minimizing post-operative muscle breakdown (catabolism), fatigue and disturbances in carbohydrate metabolism?
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
60
patients undergo hip surgery after receiving 800 ml water by mouth in the morning before the surgery.
800 ml carbohydrate drink by mouth the evening before surgery and 400 ml carbohydrate drink by mouth 2 hours before surgery
The patient is fasting from midnight before the surgery.
Södertälje Hospital
Södertälje, Södertälje, Sweden
Change in Insulin Sensitivity (Percent)
Insulin sensitivity (micro-mol per kg per minute glucose uptake) was calculated based on an intravenous glucose tolerance test (Theor Biol Med Model 2011, 8: 12) on the day before surgery. The percent change was taken as (day after - day before) / day before
Time frame: Day before surgery (approximately 3 PM) and in the morning after surgery (approx. 7.30 AM).
Muscle Catabolism
Assessed by the ratio of 3-methylhistidine/creatinine in excreted urine (unit: mmol/mmol).This is an amino acid unique to muscle that does not undergo intermediary metabolism, meaning that its urinary excretion is an index of the degree of muscle catabolism.
Time frame: From the morning after surgery (07.30) up to the morning two days after sthe surgery (07.30)
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