The purpose of this study is to explore host genetic mutations which may render individual subjects more susceptible (or resistant) to developing Progressive Multifocal Leukoencephalopathy (PML). Samples will also be collected to determine Deoxyribonucleic Acid (DNA) sequence of JC Virus (JCV). Analysis of the JC Virus (JCV) genome may provide information about viral genotypes that may be associated with higher pathogenicity, and help to identify individuals who may be at higher risk of developing Progressive Multifocal Leukoencephalopathy (PML) due to chronic infection with a more pathogenic variant of JC Virus (JCV).
Deoxyribonucleic acid (DNA) will be analyzed from natalizumab-treated subjects who develop Progressive Multifocal Leukoencephalopathy (PML). The genetic analysis of the subjects will directly seek mutations that could identify subjects at risk.
Study Type
OBSERVATIONAL
Enrollment
24
North Central Neurology Associates
Cullman, Alabama, United States
Rocky Mountain MS Center at Anschutz Medical Campus University Colorado Denver
Aurora, Colorado, United States
Rush Medical Center - Rush Multiple Sclerosis Center
Chicago, Illinois, United States
St. Vincent Hospital, St. Vincent Neuroscience Institute
Indianapolis, Indiana, United States
Central Neurology
Hastings, Nebraska, United States
Clinical Research Center UH, The Nebraska Medical Center
Omaha, Nebraska, United States
NYU Hospital for Joint Disease, MS Care Center
New York, New York, United States
University of Rochester
Rochester, New York, United States
Research Site
Cincinnati, Ohio, United States
Neurology of Bend, LLC
Bend, Oregon, United States
...and 1 more locations
to examine host genetic variation and possible genetic susceptibility to PML
Time frame: Up to 3 Months
To explore predisposing factors of the innate and adaptive immune system
Time frame: Up to 3 Months
To analyze DNA sequences of JCV
Time frame: Up to 3 Months
optional substudy: to test alterations in DNA repair pathways
Time frame: Up to 3 Months
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