This study has two aims: 1. to evaluate placental transfer of acetaminophen from mother to baby transplacentally given from 30 minutes to 24 hours prior to cesarean delivery (34 patients) 2. to understand the impact of maternal acetaminophen use on fetal movement and breathing (20 patients)
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
56
Acetaminophen 1000 mg by mouth once
Acetaminophen 1000 mg by mouth once
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Maternal and neonatal serum acetaminophen level
Pregnant women will be given 1000 mg of acetaminophen orally and have both maternal and neonatal serum acetaminophen levels checked at the time of cesarean section 30 minutes to 24 hours after administration.
Time frame: Time Frame: 30 minutes to 24 hours post administration
Fetal breathing and body movements
Pregnant women will have a baseline assessment of fetal breathing and body movements with ultrasound and will then be given 1000 mg of acetaminophen orally. Fetal breathing and body movements will then be reassessed 60 minutes later.
Time frame: Time Frame: 60 minutes
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