The Foot in Your Nose Study: Links Between Nasal Staphylococcus Aureus Colonies and Diabetic Foot Lesion Infections

Centre Hospitalier Universitaire de Nīmes278 enrolled

Overview

The presence of S aureus in the nasal passages of diabetic patients may be a risk factor for diabetic foot lesion infections. Our aim is to compare the genetic profiles of S aureus strains found in the noses and on the foot lesions of diabetic patients. The investigators are also studying the virulence of these strains, the prevalance of S aureus at either site, and whether or not the quantity of S aureus found in the nose affects the risk for infection in foot lesions. The investigators also use this study to test the sensitivity and specificity of the GeneXpert system.

Study Type

OBSERVATIONAL

Enrollment

278

Conditions

Diabetic Foot Staphylococcus Aureus

Interventions

Genetic profiling of bacterial culturesBIOLOGICAL

Genetic profiling of bacterial cultures harvested from both the nose and foot lesions of patients

Medical Language ↔ Plain English

Inclusion Criteria: * Type 1 or 2 diabetic patients * Patients consulting or hospitalized in the Diabetology departments of one of the participating centers * Grade 2-4 ulcer on the foot or ankle (both primo and recurrent events are acceptable) Exclusion Criteria: * Patient refuses to participate * Pregnant, parturient or breastfeeding women * Patient does not have diabetic foot or arteritic * Diabetic ulcer is located elsewhere than the foot or ankle * The ulcer is non-swabbable * Patient does not have social-security coverage * Patient is under any type of guardianship

Locations (4)

CHU de Nîmes - Hôpital Universitaire Carémeau

Nîmes, Gard, France

CHU de Nîmes - Hôpital Universitaire de Réadaptation du Grau du Roi

Le Grau-du-Roi, France

APHM - Hôpital Nord

Marseille, France

CHU de Montpellier - Hôpital Lapeyronie

Montpellier, France

Outcomes

Primary Outcomes

Presence/absence of the same S. aureus genetic profile in the nose and on the foot lesion.

Presence/absence of the same S. aureus genetic profile in the nose and on the foot lesion. Genetic profiles do not change with time. This is a transversal, pinpoint measure.

Time frame: 3 hours