Daptomycin Pharmacokinetics in Critically Ill Patients Undergoing Continuous Veno-venous Hemodiafiltration, a Dose Finding Study

Inclusion criteria: * male or female of 18 years or older * females: negative pregnancy test * Hospitalisation in the medical ICU * High suspicion or evidence of Gram-positive infections requiring antibiotic therapy * Subjects receiving standard antibiotic treatment for Gram-positive infection * Evidence of renal failure * Clinical necessity for continuous renal replacement therapy * Written informed consent signed by the patient or a next of kin and an independent physician in case the patient is not able to sign. Exclusion criteria: * Skeletal muscle disorders or CPK levels of \> 2 x ULN * History of hypersensitivity to the drug * Participation in another study * Subjects with a history of muscle disease * Patients with severe liver function impairment (Child * Life expectancy of less than 5 days