Effects of Propofol and Isoflurane on Pulmonary Vascular Resistance

University Hospitals Bristol and Weston NHS Foundation Trust10 enrolled

Overview

The investigators hypothesize that there is no difference between the effects of isoflurane and propofol anaesthesia on pulmonary vascular resistance (PVR).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

Conditions

Hypertension, Pulmonary

Interventions

propofol and isofluraneDRUG

both drugs administered at age-related dose and titrated to effect. maximum dose of propofol 15 mg/kg/hr, maximum dose of isoflurane 1.5 MAC

Eligibility

Sex: ALLMin age: 3 MonthsMax age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All children between 3 months and 16 years of age with pulmonary arterial hypertension undergoing a PVR study. Exclusion Criteria: * Children with a known adverse reaction to one of the study drugs eg malignant hyperpyrexia or a disorder of fatty acid oxidation.

Locations (1)

UH bristol NHS Trust

Bristol, United Kingdom

Outcomes

Primary Outcomes

The primary endpoint is the percentage change in PVR under isoflurane anaesthesia compared with propofol anaesthesia.

Time frame: 2 hours

Secondary Outcomes

The secondary endpoints are the percentage change in mean pulomanry artery pressure (PAP), systemic vascular resistance (SVR) and mean arterial pressure (MAP).

Time frame: 2 hours

Data from ClinicalTrials.gov

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