Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery

Loma Linda University70 enrolled

Overview

This is an investigator initiated, sponsored, open label, prospective randomized controlled trial to be performed in adult patients undergoing scheduled cardiac surgery. Patients will be randomized to esmolol infusion or nitroglycerin infusion for control of hypertension that occurs during cardiac surgery from induction of anesthesia to initiation of cardiopulmonary bypass (CPB).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hypertension

Interventions

nitroglycerinDRUG

nitroglycerin administered as an infusion following a step up/step down protocol to treat hypertension in patients undergoing cardiac surgery.

esmololDRUG

esmolol will be administered by infusion following a step up / step down protocol to control hypertension.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult patients scheduled for cardiac surgery at LLUMC University Hospital will be eligible for participation in this study. Exclusion Criteria: 1. severe LV (left ventricle)dysfunction (EF \< 35%). 2. emergency procedures. 3. procedures with combined carotid artery surgery. 4. patients at high risk for stroke. 5. hemodynamically significant dysrhythmias. 6. pre-existing atrial fibrillation or high degree AV (atrioventricular block). 7. pacemaker dependency. 8. known sensitivity to beta blockers. 9. patient refusal.

Locations (1)

Loma Linda University

Loma Linda, California, United States

Outcomes

Primary Outcomes

Diastolic Blood Pressure Excursions Beyond Predetermined Lower Limits, Normalized Per Hour

Area under the curve (AUC) of Diastolic Blood Pressure Excursions Beyond Predetermined Lower Limits, Normalized Per Hour from Anesthesia Induction to Initiation of Cardiopulmonary Bypass

Time frame: Participants were followed from Anesthesia Induction to Initiation of Cardiopulmonary Bypass, an average of 5 hours

Secondary Outcomes

Title: Systolic Hypertension

Area under the curve (AUC) of Systolic Blood Pressure Excursions Beyond Predetermined Upper Limits, Normalized Per Hour from Anesthesia Induction to Initiation of Cardiopulmonary Bypass

Time frame: Participants were followed from Anesthesia Induction to Initiation of Cardiopulmonary Bypass, an average of 5 hours

Data from ClinicalTrials.gov

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