* To examine differences in neurophysiologic parameters between unmedicated patients with bipolar depression and healthy controls * To examine within-subject changes in neurophysiologic parameters in patients with bipolar depression treated with quetiapine
* Alterations of neurophysiologic regulation has been suggested in patients with major depressive disorder or bipolar disorders * Depressive phase of bipolar disorder shows multi-faceted characteristics different from unipolar depression * Quetiapine is an atypical antipsychotic licensed for treatment of bipolar depression * The aim of this study is to investigate the pattern of neurophysiologic dysregulation in bipolar depression and its changes induced by quetiapine treatment
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
60
oral tablet/25-600mg per day/once a day/six weeks
Department of Neuropsychiatry, Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
RECRUITINGHeart Rate Variability
heart rate variability parameters of time/frequency/complexity domains
Time frame: Six weeks
Cardio-Respiratory Coupling
integrative parameters of interaction between neurocardiac dynamics and respiratory rhythm
Time frame: Six weeks
Electroencephalographic Changes
Electrical brain activities measured by quantitative electroencephalography
Time frame: Six weeks
Severity of Mood Symptoms
* Hamilton Depression Rating Scale * Bipolar Depression Rating Scale * Young Mania Rating Scale * Difficulties in Emotion Regulation Scale * Emotion Regulation Questionnaire
Time frame: Six weeks
Severity of Extrapyramidal Symptom Scale
Drug-Induced Extrapyramidal Symptom Scale
Time frame: Six weeks
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