High Intensity Non-Invasive Positive Pressure Ventilation (HINPPV)

Inclusion Criteria 1. Patient diagnosed with chronic obstructive pulmonary disease (COPD) 2. Age \< or = to 80 years 3. Forced expiratory volume in one second (FEV1) \< 50% of predicted value 4. FEV1/Forced vital capacity (FVC) \< 70% of predicted value 5. Total lung capacity (TLC) \> 90% predicted by plethysmography 6. Body Mass Index (BMI) \< 35 7. Patient has provided written informed consent using a form that has been approved by the Internal Review Board (IRB) 8. Daytime PaCO2 ≥ 52 mm Hg, at rest on room air (Denver \> 48 mm Hg) with one of the following symptoms of hypercapnia: * Fatigue * Sleepiness * Headaches 9. Post hospital discharge at least one month prior to screening visit 10. Participant is willing and able to complete all required assessments and procedures 11. Participant has no child bearing potential OR a negative pregnancy test in a woman of childbearing potential Exclusion Criteria 1. FEV1 \< 15% of predicted value 2. Diagnosis of obstructive sleep apnea (OSA) \[Apnea hypopnea index (AHI) \> 15 per hour\] 3. Current Non-invasive Positive Pressure Ventilation (NIPPV), Positive Airway Pressure (PAP) or Non-invasive Ventilation (NIV) users 4. Signs / symptoms of acute exacerbation within the previous month: two of the following criteria: * Increasing cough * Purulent sputum * Current use of antibiotics * pH \< 7.35 5. Any major non COPD disease or condition that interferes with completion of initial or follow-up assessments, such as uncontrolled malignancy, end-stage heart disease, liver or renal insufficiency (that requires current evaluation for liver or renal transplantation or dialysis), amyotrophic lateral sclerosis, or severe stroke, or other as deemed appropriate by investigator as determined by review of medical history and / or patient reported medical history 6. History of pneumothorax 7. Anatomical facial abnormalities precluding placement of a nasal or facial mask 8. Diffuse parenchymal lung disease other than emphysema 9. Inability to maintain Oxygen (O2) saturation \>90% on 5L/min ( five liters) nasal O2 at rest 10. Sustained need for \>10 mg prednisone daily or equivalent dose of other systemic corticosteroid 11. Pregnancy 12. Excessive alcohol intake (≥ 6oz hard liquor daily), or illicit drug use 13. Daily use of narcotics (greater than 30 mg morphine equivalent) 14. Patient is currently enrolled in another interventional clinical trial