Assessment of the Natural Antibody Response to Pneumococcal Surface Proteins During Acute Otitis Media in Children

NasVax Ltd100 enrolled

Overview

This clinical study is designed to assess prospectively the sero-responses to various proteins in cases of pneumococcal Acute Otitis Media.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Acute Otitis Media

Eligibility

Sex: ALLMin age: 3 MonthsMax age: 3 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male and female Jewish and Bedouin children. * Patients can be either ambulatory or hospitalized. * Presenting with acute otitis media. * Tympanocentesis was performed at least in one ear for a clinical indication. * Culture of middle ear fluid was obtained. * Parents agreeing to participate in the study and to submit their children for follow-up, blood test and nasopharyngeal/oropharyngeal (NP/OP) cultures. Exclusion Criteria: * Having another infection that is likely to be caused by S. pneumoniae. * Known immunodeficiency. * Known previous recent pneumococcal infections (\<1 month prior to current visit).

Locations (1)

Ben-Gurion University of the Negev

Beersheba, Israel

RECRUITING

Outcomes

Primary Outcomes

Serological studies of pneumococcal proteins and their development over time following otitis media infections

The serological studies will study the natural immune response to protective pneumococcal vaccine antigens.

Time frame: 3 months per individual

Data from ClinicalTrials.gov

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