The main objective is to investigate the postprandial effect of arginine-rich protein (i.e. pea-protein) on metabolic control, inflammation and endothelial function after a high-fat meal in subjects with characteristics of the metabolic syndrome.
Arginine is potential interesting considering the metabolic syndrome. Studies so far indicated both long-term effects, as well as acute - postprandial - actions; especially when metabolism is already challenged, e.g. in diabetic patients or after a high-fat meal. If arginine-rich proteins are equally effective is not known. Therefore we are interested in the effect of (arginine rich) protein on postprandial (dys)metabolism, inflammation and endothelial function, within 6 hours after a meal.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
18
Shake containing 95 gram of fat, additive 30 gram pea protein
Shake containing 95 gram of fat, additive 30 gram gluten protein hydrolysate
Shake containing 95 gram of fat, no protein additive
Wageningen University, Division of Human Nutrition
Wageningen, Gelderland, Netherlands
Postprandial metabolic, inflammatory and endothelial response
Metabolic: Plasma glucose, insulin and triglyceride levels (T= 0,1,2,3,4,5 and 6 hrs) Inflammatory: C-reactive protein (CRP), Plasminogen activator inhibitor-1 (PAI-1), Tumor necrosis factor-alpha (TNF-a), Interleukin-6 (IL-6), Inter-Cellular Adhesion Molecule-1 (ICAM-1) and Monocyte chemotactic protein-1 (MCP-1) (T=0, 2, 4 and 6 hrs). Endothelial function: Macro vascular regional arterial stiffness by Pulse Wave Analysis (PWA) (T=0, 3 and 6 hrs).
Time frame: up to 6 hours
Satiety markers and Oxidative stress
Satiety: Glucagon-like peptide-1 (GLP-1) (T=0,2,4 and 6 hrs). Oxidative stress: Peripheral blood mononuclear cells (PBMC) (T=0,3 and 6 hrs).
Time frame: up to 6 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Shake containing 95 gram of fat, additive 30 gram gluten protein.
Shake containing 95 gram of fat, additive 30 gram gluten gluten hydrolysate