Vancomycin-Associated Nephrotoxicity

University at Buffalo398 enrolled

Overview

The primary goal of this study is to determine if there is an association between greater exposure to vancomycin and the development of nephrotoxicity. The secondary goal is to estimate the costs to the hospital associated with these nephrotoxic events.

Study Type

OBSERVATIONAL

Enrollment

398

Conditions

Nephrotoxicity

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years or older at time of hospital admission * Had an absolute neutrophil count of ≥ 1000 cells/mm\^3 * Received \> 48 hours of intravenous vancomycin therapy * Had one or more vancomycin trough levels reported within the 96 hours after therapy initiation * Had a baseline serum creatinine level of \< 2.0 mg/dL and baseline creatinine clearance level of ≥ 30 mL/min Exclusion Criteria: * Previous diagnosis of cystic fibrosis

Locations (1)

University of Rochester Medical Center

Rochester, New York, United States

Outcomes

Primary Outcomes

Time to nephrotoxicity

Time frame: within 72 hours post completion of vancomycin therapy

Secondary Outcomes

Hospital costs

Time frame: until discharge

Length of stay

Time frame: until discharge

Data from ClinicalTrials.gov

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