Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease with high prevalence worldwide and with relevant impact on patient-related quality of life, morbidity and mortality. There is evidence that airway inflammation correlates with the severity of the disease and that airway inflammation is further enhanced during exacerbation. However, it is unknown whether daily fluctuation of symptoms or changes in lung function is paralleled by changes in airway inflammation.
Patients will undergo a visit every 7 days during one month (5 visits in total). At each visit airway inflammation (exhaled NO, sputum inflammatory cell count) and lung function will be performed. At home patients will be asked to fill a daily diary for symptom assessment.
Study Type
OBSERVATIONAL
Enrollment
40
Patients, will be asked to continue their previous medication (GOLD guidelines) during the study. No interventional change in COPD treatment will be performed during the study.
Research Centre on Asthma and COPD - Department of Clinical and Experimental Medicine - Section of Respiratory Disease - University of Ferrara
Ferrara, Italy
Correlation between changes in airway inflammation and symptom score
Correlation between changes in airway inflammation and symptom score will be evaluated
Time frame: 1 month,
Correlation between changes in airway inflammation and lung function
Correlation between changes in airway inflammation and lung function will be evaluated
Time frame: 1 month
Correlations between airway inflammation and symptom scores
Correlation between markers of airway inflammation and symptom score will be performed
Time frame: 1 month
Correlations between airway inflammation and lung function
Correlation between markers of airway inflammation and lung function will be assessed
Time frame: 1 month
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