Evaluation of the Effect of the InsuPatch Device on Insulin Pharmacokinetics in Clamp Studies

Inclusion Criteria: 1. Age between 18- 65 years old (including = 18 years and =65 years) 2. Gender: men and women 3. BMI: 18-35 kg/m2 4. Type 1 Insulin dependent diabetes using the MiniMed paradigm insulin pumps for at least six months and using insulin Lispro or Insulin Aspart. 5. Diabetic subjects with HbA1c values below 9.5% (including 9.5%). 6. Subject understands the study requirements and the treatment procedures and has signed an Informed Consent before any study-specific tests or procedures are performed 7. Subject is willing to comply with all specified follow-up evaluations - Exclusion Criteria: 1. Pregnancy 2. Breast feeding women. 3. Alcohol addiction 4. Had CABG (Coronary Artery Bypass Graft), are Post MI (Myocardial Infarction) or had active Ischemic heart disease prior to the study date 5. Had CVA (cardiovascular accident) or TIA (transient ischemic accident) prior to the study 6. Suffer from uncontrolled Hypertension (blood pressure in mm HG \>160 systolic or \> 95 diastolic) 7. Low blood hemoglobin concentration \<9 g/dL for female and \<11g/dL for male. 8. Abnormal kidney and/ or liver function tests. (If any of the liver or kidney function test parameters are greater than 3 fold normal values. 9. Subjects with Hyperthyroidism or Hypothyroidism with TSH level outside the normal range, TSH\>5.5 mIU/L or TSH\<0.4 mIU/L 10. Psychological incompetence 11. Any other clinical condition or history, that seems to be relevant to the principle investigator to disqualify the participant. 12. Subjects with diminished skin integrity 13. Subjects with heat sensitivity 14. Subjects involved in or planed to participate in other studies 15. Subjects using other drugs therapies to control blood glucose level other than insulin.