Study of Resistance Strengthening Versus Ambulation Post-Liver Transplant

University of Miami52 enrolled

Overview

Resistance strengthening exercise will increase strength and functional activity greater than ambulation in subjects post-liver transplantation.

Individuals post liver transplantation are significantly muscle wasted due to chronic liver disease. Current Usual care only involves progressive ambulation. Resistance exercise targeted at the lower extremities are anticipated to increase muscle strength in the muscles that extend the hip, extend the knee, and plantar flex the ankle more than seen with the usual care ambulation. The anticipated increases in strength should improve functional performance of activities such as standing from a chair, walking, and climbing stairs. The improvement in strength and functional performance should improve an individuals quality of life.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Liver Transplantation Resistance Training Activities of Daily Living

Interventions

Resistance Strengthening Exercise ProgramOTHER

Home exercise Program. 3-4 days a week. 30 minutes a session. 12 weeks

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Undergone Liver Transplantation a minimum of 6 weeks and a maximum of 12 weeks prior to enrollment * Ambulatory without physical assistance, but permitted to use a cane or walker Exclusion Criteria: * Diagnosis of Hepatocellular Carcinoma * Significant Cardiopulmonary disease * Neurological / Neuromuscular Disorder including cerebral vascular accident (CVA), Parkinson's Disease, Alzheimer's Disease, Dementia unrelated to Hepatic Encephalopathy, dystonia, multiple sclerosis, and polio. * Blindness * Inability to comprehend the English or Spanish Language

Locations (1)

University of Miami Department of Physical Therapy

Coral Gables, Florida, United States

Outcomes

Primary Outcomes

Six Minute Walk Test

Time frame: Baseline

Heel Rise Test

Time frame: Baseline

30-Second Chair-Stand Test

Time frame: Baseline

Bridge Test

Time frame: Baseline

Six Minute Walk Test

Time frame: 12 weeks

Heel Rise Test

Time frame: 12 weeks

30-Second Chair-Stand Test

Time frame: 12 weeks

Bridge Test

Time frame: 12 weeks

Secondary Outcomes

Short Form (SF-36) Questionnaire

Time frame: Baseline

Short Form (SF-36) Questionnaire

Time frame: 12 weeks

Chronic Liver Disease Questionnaire (CLDQ)

Time frame: Baseline

Chronic Liver Disease Questionnaire (CLDQ)

Time frame: 12 weeks

Data from ClinicalTrials.gov

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