Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children

Chongqing Medical University47 enrolled

Overview

The purpose of this study is planned to investigate whether small doses of methylprednisolone pulse macrolide therapy can relieve symptoms,chest X-rays faster than macrolide alone therapy for refractory mycoplasma pneumoniae pneumonia(MPP) .

Corticosteroid has been used in adulthood refractory MPP with satisfactory efficacy. But there were few studies about the use of corticosteroid in children with refractory MPP. Lee KY et al indicated oral prednisolone of 1 mg/kg/ day for 1 week be useful for children with severe MPP. Akihiro T et al demonstrated that intravenously administered methylprednisolone at a dose of 30 mg/kg once daily for 3 consecutive days had an efficacious treatment for children with refractory MPP.But the methods of corticosteroid use, such as the dosage, administration route, duration of treatment have not been well understood. So in this study, we planned to investigate whether small doses of methylprednisolone pulse macrolide therapy can relieve symptoms,chest X-rays faster than macrolide alone therapy for refractory mycoplasma pneumoniae pneumonia in a prospective, open-label fashion. PMID: 11096025 PMID: 18033831 PMID: 10434547 PMID: 16437541 PMID: 18656264

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Refractory Mycoplasma Pneumoniae Pneumonia

Interventions

methylprednisoloneDRUG

treatment patients were iv methylprednisolone pulse azithromycin for 5 days.

azithromycinDRUG

control patients were iv azithromycin for 5 days.

Eligibility

Sex: ALLMin age: 3 YearsMax age: 11 Years

Medical Language ↔ Plain English

Inclusion Criteria: * mycoplasma pneumoniae pneumonia * prolonged fever and deterioration of radiological findings despite macrolides treatment for 7 days or more. Exclusion Criteria: * chronic cardiac and pulmonary disease * immunodeficiency * requiring mechanical ventilation * with other pathogens detected during pneumonia.

Outcomes

Primary Outcomes

efficacy of methylprednisolone pulse macrolide therapy for children with refractory MPP.

compare the temperature , infiltration absorption,atelectasis resolution, pleural effusion disappearance,serum levels of ferritin and LDH between methylprednisolone pulse macrolide therapy group and macrolide therapy group .

Time frame: 3-year

Secondary Outcomes

safety of methylprednisolone pulse macrolide therapy for children with refractory MPP.

observe the further complications of infection between methylprednisolone pulse macrolide therapy group and macrolide therapy group .

Time frame: 3-year

Data from ClinicalTrials.gov

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