Creatine Supplementation in Pediatric Rheumatology

University of Sao Paulo40 enrolled

Overview

Creatine supplementation may improve strength, muscle mass, bone mass and muscle function in healthy and elderly people. The investigators speculate that creatine supplementation could have therapeutic effects in pediatric rheumatic (i.e., juvenile systemic lupus erythematosus and juvenile dermatomyositis) patients who usually present muscle weakness, muscle wasting and bone mass loss.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Juvenile Systemic Lupus Erythematosus Juvenile Dermatomyositis

Interventions

creatineDIETARY_SUPPLEMENT

5g/d throughout 12 weeks

placebo (dextrose)DIETARY_SUPPLEMENT

5g/d throughout 12 weeks

Eligibility

Sex: ALLMin age: 6 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients diagnosed with lupus systemic erythematosus and juvenile dermatomyositis * physically inactive * stable pharmacological treatment Exclusion Criteria: * macroalbuminuria * GFR \< 30 mL/min/1.73m2 * use of oral anticontraceptive agents * pregnancy * diabetes mellitus * hypothyroidism

Locations (1)

University of Sao Paulo

São Paulo, São Paulo, Brazil

RECRUITING

Outcomes

Primary Outcomes

muscle strength

Time frame: after six months

Secondary Outcomes

kidney function parameters

Time frame: after six months

quality of life

Time frame: after six months

muscle function

Time frame: after six months

Central Contacts

Bruno Gualano, PhD

CONTACT

551130913096 gualano@usp.br

Data from ClinicalTrials.gov

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