Therapeutic Innovation in Type 2 DIABetes (IT-DIAB)

Inclusion Criteria: * Adult patients (≥18 years) * Subjects with diabetes risk score ≥ 15 * Subjects with impaired fasting glucose: blood glucose ≥ 1.10 g/l and \< 1 .26 g/L * Subjects affiliated with an appropriate social security system Exclusion Criteria: * Fasting glycemia ≥ 1.26 g/l * Fasting glycemia ≤ 1.10 g/l * Subjects previously treated with oral anti-diabetic: metformin, glitazones, inhibitors of α-glucosidase, sulfonylurea, repaglinide, inhibitors of DPP-IV, GLP-1 R agonists. * Subjects previously treated with insulin, except gestational diabetes * Severe coagulation disorders * Thrombocytopenia \< 100 000/mm 3 * Severe psychiatric disorders * Severe renal insufficiency (creatinine clearance \< 30 ml/min) * Severe hepatic insufficiency (TP \< 50%) * Alcohol abuse (\> 30g/j) * Patient's opposition * Subject unable to follow the study during the 5 years of follow-up * Subject exclusion period in a previous study