Many patients undergo cardiac surgery without proper suspension of antiaggregation drugs. This is blamed to increase dramatically bleeding and use of allogenic blood transfusions. The investigators test the hypothesis that routine use of aggregometry could show antiaggregated patient and lead to normalization of platelet function via administration of Desmopressin thus limiting bleeding and transfusions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
200
Patients undergo standard thromboelastography and subsequent aggregometry to test effectiveness of residual antiaggregation drugs. Patients found to have altered value undergo optimization with desmopressin.
Patients undergo standard of care Thromboelastography to evaluate overall coagulation performance.
European Hospital
Rome, Italy
Bleeding Volume
Total amount of bleeding in the first 12 hours after cardiac surgery expressed as milliliters of blood in the chest drains reservoir.
Time frame: 12 hours after end of operation
Use of allogenic blood transfusions.
Number of allogenic blood units transfused per patients during the full hospital stay, usually 5 to 8 days after operation.
Time frame: In hospital stay (usually 5 to 8 days after operation)
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