This study will evaluate the safety and efficacy of first-line treatment with a free combination (as two separate pills) of nebivolol and lisinopril in patients with stage 2 diastolic hypertension (DBP\>= 100 mmHg).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
664
nebivolol 5-mg and lisinopril 10-mg (nebivolol non-trade 5-mg tablet and overencapsulated lisinopril 10-mg tablet)/QD/oral administration/up to 12 weeks nebivolol 20-mg and lisinopril 40-mg (nebivolol non-trade 20-mg tablet and overencapsulated lisinopril 40-mg tablet)/QD/oral administration/up to 10 weeks nebivolol 5-mg and lisinopril 40-mg (nebivolol non-trade 5-mg tablet and overencapsulated lisinopril 40-mg tablet)/QD/oral administration/up to 6 weeks nebivolol 20-mg and lisinopril 10-mg (nebivolol non-trade 20-mg tablet and overencapsulated lisinopril 10-mg tablet/QD/oral administration/up to 6 weeks
nebivolol 5-mg (non-trade 5-mg tablet)/QD/oral administration/up to 12 weeks nebivolol 10-mg (non-trade 10-mg tablet/QD/oral administration/for 1-week down-titration period only) nebivolol 20-mg (non-trade 20-mg tablet)/QD/oral administration/up to 10 weeks
The Change From Baseline in Trough Seated Diastolic Blood Pressure at Week 6.
Time frame: Visit 6/(Week 0) and Visit 9/(Week 6)
The Change From Baseline in Trough Seated Systolic Blood Pressure at Week 6.
Time frame: Visit 6/(Week 0) and Visit 9/(Week 6)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
lisinopril 10-mg (overencapsulated 10-mg tablet)/QD/oral administration/up to 12 weeks lisinopril 40-mg (overencapsulated 40-mg tablet)/QD/oral administration/up to 10 weeks
Placebo tablet, oral administration/QD/oral administration/up to 12 weeks Placebo capsule, oral administration/QD/oral administration/up to 12 weeks
Forest Investigative Site #58
Scottsdale, Arizona, United States
Forest Investigative site 080
Tempe, Arizona, United States
Forest Investigative site 096
Tucson, Arizona, United States
Forest Investigative site 038
Buena Park, California, United States
Forest Investigative site 075
Burbank, California, United States
Forest Investigative site 042
Costa Mesa, California, United States
Forest Investigative site 028
Fountain Valley, California, United States
Forest Investigative site 064
Fresno, California, United States
Forest Investigative site 079
Lancaster, California, United States
Forest Investigative site 097
Long Beach, California, United States
...and 80 more locations