The purpose of this study is to detect acute febrile episodes and dengue infection in five Asian countries, to assess dengue seroprevalence, and to assess surveillance infrastructure at investigational sites in anticipation of a Phase 3 efficacy trial of a vaccine to prevent dengue infection. The primary objectives are: * To identify acute febrile episodes among the cohort in order to detect the presence of dengue infection. * To develop operational infrastructure for potential Phase III dengue efficacy trial sites. * To describe the dengue seroprevalence among the cohort at baseline and at the end of the study.
All participants will make two visits to a study site, an enrollment visit and a termination visit. Additional visits will be made if febrile episodes occur: an acute visit and a convalescent visit. Participants or their parents/guardians will be contacted weekly to monitor the occurrence of febrile episodes and ensure appropriate assessment and care. No vaccine will be provided or administered in this study.
Study Type
OBSERVATIONAL
Enrollment
1,500
Unnamed facility
Bali, Indonesia
Unnamed facility
Bandung, Indonesia
Unnamed facility
Jakarta, Indonesia
Unnamed facility
George Town, Malaysia
Unnamed facility
Kuala Lumpur, Malaysia
Unnamed facility
Putrajaya, Malaysia
Unnamed facility
Cebu City, Philippines
Unnamed facility
City of Muntinlupa, Philippines
Unnamed facility
San Pablo, Philippines
Unnamed facility
Bangkok, Thailand
...and 1 more locations
To provide information on the incidences of febrile episodes and confirmed and probable Dengue fever, and to determine other causes of febrile episodes in the cohort population
Time frame: Up to 12 months after enrollment
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