The study will investigate whether dietary modification could provide positive effects on brain functions in elderly people with mild cognitive impairment.
The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as Alzheimer's disease are a growing public-health concern with devastating effects. Referring to animal data, empirical studies, and pilot human trials, dietary modification (caloric restriction, omega-3 fatty acids and resveratrol) should improve cognitive functions such as learning and memory. To test this hypothesis, the researchers study general brain functions in elderly subjects (50-80 years old) with mild cognitive impairment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
330
6 months of caloric restriction (15 %)
6 months of omega-3 supplementation
6 months of resveratrol supplementation
Department of Neurology, Charité Universitätsmedizin Berlin
Berlin, Germany
Alzheimer's Disease Assessment Scale - cognitive subscale
Time frame: Prior to intervention and after 6 months of intervention
Functional/Structural brain changes
Time frame: Prior to intervention and after 6 months of intervention
Plasma biomarkers
Time frame: Prior to intervention and after 6 months of intervention
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6 months of placebo intake
most effective dietary intervention plus physical and cognitive training
most effective dietary intervention plus control