The main aim of the study is to determine whether intramuscular injection of umbilical cord mesenchymal stem cells can improve the ventricular function of children with idiopathic dilated cardiomyopathy(IDCM); Secondary end-points will be: 1)To explore the possible mechanism of the improvement of ventricular function in children with IDCM and 2) to evaluate the safety of intramuscular injection of umbilical cord mesenchymal stem cell.
Children with Idiopathic dilated cardiomyopathy class II to III NYHA with ejection fraction over 20% were selected for phase II clinical trial, umbilical cord mesenchymal stem cells were injected into limb muscle and followed for 6 months.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Multiple intra muscular injection of mesenchymal stem cells derived from human umbilical cord.
Stem Cell Research Center of Medical School Hospital of Qingdao University
Qingdao, Shandong, China
echocardiography
Time frame: 3 months
24h HOLTER
Time frame: 2 months
The level of serum BNP,TNI,HGF、LIF and G/M-CSF
Time frame: 3 months
The expression level of c-kit,CD31,CD133 on peripheral blood mononuclear cells
Time frame: 2 months
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