Many persons with Multiple Sclerosis ( MS) have problems with memory and thinking.Exercise has been shown to improve memory and thinking in persons with diseases such as Alzheimer's. This study will investigate whether a program of aerobic exercise can improve memory and thinking in persons with MS
Persons with Multiple Sclerosis(MS)will be screened for eligibility and randomized to a protocol with two intervention arms. One group will have aerobic training on a recumbent cross trainer three times a week for 20-30 minutes/session. The other group will participate in stretching exercises at the same frequency and intensity.Total training time will be six months.Outcome measures will include tests of memory and thinking, and fitness measures.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
35
subjects will participate in one of two forms of exercise
subjects will particiopate in supervised stretching as described in arm description.
UCalifornia at Los Angeles
Los Angeles, California, United States
CAl State University at Northridge
Northridge, California, United States
Paced Auditory Serial Addition Test (PASAT)
test of attention and information processing
Time frame: 36 weeks
Symbol Digit Modalities Test (SDMT)
test of attention and information processing
Time frame: 36 weeks
VO2 max
measure of fitness via oxygen consumption and use
Time frame: 36 weeks
Long latency cognitive event related potentials ( LLCERP)
electrophysiologic tests of information processing
Time frame: 36 weeks
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