Attenuation of Pain in Men and Women

N/ACompletedNCT01220414

University of Wisconsin, Madison60 enrolled

Overview

The purpose of this study is to examine opioid and endocannabinoid mechanisms of exercise-induced analgesia in men and women.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Pain

Interventions

Naltrexone, then placeboDRUG

50 mg of naltrexone

Placebo, then NaltrexoneDRUG

sugar pill

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Healthy men and women \- Exclusion Criteria: * current cardiac or other chronic diseases (e.g., cancer, diabetes, hypertension, kidney disease); routine use of prescriptive medications; history of vasovagal response to phlebotomy; an allergy to naltrexone; pregnancy; current smokers; current use of recreational drugs; history of substance abuse

Locations (1)

University of Wisconsin-Madison

Madison, Wisconsin, United States

Outcomes

Primary Outcomes

Time for Subject to Reach Pain Threshold

Time frame: Baseline

Data from ClinicalTrials.gov

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