Methylprednisolone Addition in IVF Treatment of Infertile Couples

Phase 4UnknownNCT01220791

Universitair Ziekenhuis Brussel130 enrolled

Overview

Hypothesis to be tested is whether follicular addition of Methylprednisolone can efficiently control late follicular progesterone rise during IVF treatment

The aim is to investigate any potential advantages of adding cortisone supplementation from the follicular phase onwards with regard to premature luteinization, oocyte quality, embryo quality and pregnancy outcome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

130

Conditions

In Vitro Fertilization

Interventions

In vitro fertilization treatment for infertilityOTHER

IVF treatment

Eligibility

Sex: FEMALEMin age: 21 YearsMax age: 36 Years

Medical Language ↔ Plain English

Inclusion Criteria: * less than 36, more than 10 antral follicles, FSH\<12 Exclusion Criteria: * endometriosis stage III\&IV,

Locations (1)

Biogenesis

Thessaloniki, Pylaia, Greece

RECRUITING

Outcomes

Primary Outcomes

Progesterone rise above 1.5ng.ml on the day of HCG

Incidence or high progesterone on the day of HCG triggering

Time frame: up to 14 days of follicular ovarian stimulation

Secondary Outcomes

Clinical pregnancy rate

Success rate in IVF cycles

Time frame: Follow pregnancy until delivery

Central Contacts

Evangelos Papanikolaou, MD

CONTACT

0030 2310 424284 drvagpapanikolaou@yahoo.gr

Data from ClinicalTrials.gov

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