A Study of Fostamatinib in Subjects With Impaired Hepatic (Liver) Function

Inclusion Criteria: * Males and females (non child-bearing potential) aged 18 years or more, with a weight of at least 50 kg and body mass index (BMI) between 18 and 40 kg/m2 inclusive * Healthy subjects only: good health as determined by a medical history, physical examination , ECG and clinical laboratory evaluations * Healthy subjects only: negative results for serum hepatitis B and C Exclusion Criteria: * Subjects who have received any medications known to alter drug absorption or elimination within 30 days of first dose. * Subjects who smoke more than 10 cigarettes or equivalent per day * Absolute neutrophil count \<2500/mm3 * Abnormal vital signs, additional systemic disease (eg, cardiac, or renal disease) or abnormal laboratory findings that are judged to be clinically significant by the investigator * Healthy volunteers only: use of prescribed medications within 2 weeks of first dose or use of non-prescribed medications within 1 week of first dose * Hepatic subjects only: fluctuating or rapidly deteriorating hepatic function