10 healthy volunteers will undergo the controlled lowering of their blood glucose level at sea level and a simulated altitude of 8,000 feet, to test the hypothesis that continuous glucose monitoring system measurement of blood glucose is as accurate at altitude as at sea level.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
10
Study participants will have their blood glucose stabilized between 5 - 6 mmol/L by the delivering of a controlled rate insulin/glucose infusion. Participants will have their blood glucose level reduced by conducting a controlled two step hyperinsulinaemic glucose clamp. The clamp procedure will take a total of 120 minutes and will reduce the blood glucose level to below 3 mmol/L. During this time blood tests will be obtained for analysis, physical observations recorded and cognitive function tests performed at regular intervals. Participants will have been fitted at least 12 hours prior to the intervention with 2 real time continuous glucose monitoring systems which will remain in place for the duration of the clamp procedure, however participants will be blinded to their glucose readings.
Royal Airforce Base Henlow
Henlow, Bedfordshire, United Kingdom
Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
Bournemouth, Dorset, United Kingdom
Accuracy of continuous glucose monitoring system (CGMS).
To evaluate the accuracy of CGMS for glucose measurement at altitude (8,000 ft) in healthy volunteers.
Time frame: One year.
The effect of altitude on the recognition of hypoglycaemic symptoms.
To examine the effect of high altitude (8,000 ft) on the recognition of hypoglycaemia in healthy volunteers.
Time frame: One year.
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