The primary aim of this study is to investigate, whether higher intake of selenium rich food items such as fish and shellfish, is associated with higher selenium blood levels. The secondary aim is to investigate the uptake of selenium from fish and shellfish and the incorporation of selenium from those foods into proteins in the human body. Furthermore, the impact of the natural variation in the genes that are responsible for the accumulation of selenium in the proteins will be investigated.
Selenium is an essential trace element that is incorporated into proteins in the human body and it hereby plays a major role in several important cellular processes. Previous studies have indicated that the selenium status of the Danish population is below the levels required to optimize the suggested protective effects of selenium towards major diseases including cancer. In Denmark, important natural sources of selenium are fish and shellfish.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
102
Intake of 1000 grams of fish and shellfish per week for six months.
Institute of Cancer Epidemiology, Danish Cancer Society
Copenhagen, Denmark
Selenium concentration in whole blood
Time frame: Measured at baseline
Selenium concentration in whole blood
Time frame: Measured after 3 months of intervention
Selenium concentration in whole blood
Time frame: Measured after 6 months of intervention
Selenoprotein P in plasma
Time frame: Measured at baseline
Selenoprotein P in plasma
Time frame: Measured after 3 months of intervention
Selenoprotein P in plasma
Time frame: Measured after 6 months of intervention
Genetic polymorphisms in the selenoprotein P gene
Time frame: Measured at baseline
Genetic polymorphisms in the selenoprotein P gene
Time frame: Measured after 3 months of intervention
Genetic polymorphisms in the selenoprotein P gene
Time frame: Measured after 6 months of intervention
Heavy metals in whole blood (lead, cadmium, and mercury)
Time frame: Measured at baseline
Heavy metals in whole blood (lead, cadmium, and mercury)
Time frame: Measured after 3 months of intervention
Heavy metals in whole blood (lead, cadmium, and mercury)
Time frame: Measured after 6 months of intervention
Blood pressure
Time frame: Measured at baseline
Blood pressure
Time frame: Measured after 3 months of intervention
Blood pressure
Time frame: Measured after 6 months of intervention
Anthropometry (weight, height, waist, and hip circumference)
Time frame: Measured at baseline
Anthropometry (weight, height, waist, and hip circumference)
Time frame: Measured after 3 months of intervention
Anthropometry (weight, height, waist, and hip circumference)
Time frame: Measured after 6 months of intervention
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.