Safety and Immunogenicity Study to Assess TDV, a Live Attenuated Tetravalent Vaccine for Prevention of Dengue Fever

Inclusion Criteria: * Is male or female aged 18 to 45 years, inclusive, at time of screening. * Is in good health as determined by medical history, physical examination, and clinical safety laboratory examinations. * Has body mass index (BMI) in the range 18-27 kilogram per square meter (kg/m\^2). * Has negative serology for Human Immunodeficiency Virus (HIV), Hepatitis C antibody, and Hepatitis B surface antigen. * Females of child bearing potential must have a negative urine pregnancy test result during screening and a negative urine pregnancy test immediately prior to vaccination and be willing to use oral, implantable, transdermal or injectable contraceptives or another reliable means of contraception approved by the Investigator (intrauterine device, female condom, diaphragm with spermicidal, cervical cap, use of condom by the sexual partner or a sterile sexual partner, or abstinence) from screening until after the last blood sample (at Day 270). * Is willing and able to give written informed consent to participate. * Is willing and able to communicate with the Investigator and understand the requirements of the study. Exclusion Criteria: * Has any condition which would limit the participant's ability to complete the study. * Clinically significant hematological, renal, hepatic, pulmonary, central nervous system, cardiovascular or gastrointestinal disorders. * Has abnormal electrocardiogram (ECG). * Has febrile illness (temperature greater than or equal to (\>=) 38 degree Celsius (°C) or 100.4 degree Fahrenheit (°F) or moderate or severe acute illness or infection within three days of vaccination. * Diabetes mellitus. * Has allergy to penicillin, neomycin, streptomycin or gentamicin. * Hypersensitivity to any vaccine. * Seropositivity to any of the four dengue serotypes (TDV-1, TDV-2, TDV-3 or TDV-4), yellow fever (YF) virus or West Nile (WN) virus. * Has previous vaccination (in a clinical trial or with an approved product) against flaviviruses including dengue, YF or WN. * Has planned vaccination against YF throughout the duration of this study. * Has receipt of any vaccine in the 4 weeks preceding the first trial vaccination. * Planned receipt of any vaccine in the 4 weeks following each of the vaccinations in this study. * Travel to dengue-endemic areas in the two months prior to study start or planned travel to dengue-endemic areas during the study period, including low altitude regions of Colombia where dengue is endemic. * Known or suspected congenital or acquired immunodeficiency, immunosuppressive therapy such as anti-cancer chemotherapy or radiation therapy within the preceding 6 months prior to the first vaccination, or long- term (at least 2 weeks within the previous 3 months) systemic corticosteroids therapy (at a dose of at least 0.5 milligram per kilogram per day \[mg/kg/day\]) prior to the first vaccination. * Has a history of recurring migraines or on prescription medication for treatment of recurring headaches or migraines. * Use of any non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen or antihistamines for the 3 days immediately prior to each vaccination. * Use of prescription or over the counter medications 7 days before the first vaccination (Day 0), excluding contraceptives and painkillers containing NSAIDs or acetaminophen, cold remedies, hormone replacement and antihistamines. * Positive urine screen for cocaine, amphetamines, opiates, or cannabinoids. * Receipt of any other investigational product or participation in any other clinical trial in the month before the first vaccination (Day 0) or during the conduct of this study. * Receipt of blood products or immunoglobulins 8 weeks before the first vaccination (Day 0) or planned use during the study period. * Donation of blood 6 weeks before the first vaccination (Day 0) or at any time during the study. * Females who are pregnant or lactating.