Single and Multiple Oral Administration Study of ASP015K in Healthy Nonelderly Volunteers

Inclusion Criteria: * Healthy judged by the investigator or subinvestigator on the basis of physical examination and all test results * Weight * Japanese: ≥ 50.0 kg to \< 80.0 kg * Caucasians: ≥ 50.0 kg to \< 100.0 kg * BMI * Japanese: ≥ 17.6 kg/m2 to \< 26.4 kg/m2 * Caucasians: ≥ 18.0 kg/m2 to \< 30.0 kg/m2 * Written informed consent obtained from the subject personally Exclusion Criteria: * Administered drug in another clinical study or a post-market clinical study in the 120 days prior to the study * Collection of 400 mL of whole blood within 90 days prior to the study, 200 mL of whole blood within 30 days prior to the study or blood components within 14 days prior to the study * Received or is scheduled to receive drug treatment within 7 days prior to the drug administration * A history of drug allergies * Upper gastrointestinal symptoms, e.g., nausea, vomiting or stomachache, within 7 days prior to the drug admission * Concurrent or previous liver disease, e.g., viral hepatitis or drug-induced hepatic injury * Concurrent or previous heart disease, e.g., congestive heart failure, angina pectoris or arrhythmias requiring treatment * Concurrent or previous kidney disease, e.g., acute renal failure, glomerulonephritis or interstitial nephritis (except for previous urinary calculus) * Concurrent or previous cerebrovascular disease, e.g., cerebral infarction * Concurrent or previous malignancy * Concurrent or previous active or recurrent infection, e.g., hepatitis B, hepatitis C or syphilis