Statin/Vitamin D & Migraine Study

Rami Burstein89 enrolled

Overview

The investigators are studying if taking simvastatin and vitamin D together will help prevent episodic migraines. Simvastatin is an FDA approved drug that is typically used to treat high cholesterol and reduce the risk of stroke and heart attack. Vitamin D is a vitamin found in certain foods like some types of fish, and in nutritional supplements. This study is 9 months long. Some people who participate will receive simvastatin and vitamin D, and some people will receive a placebo. A placebo is a "sugar pill" that looks like medication but does not have any active ingredients in it. The investigators hypothesize that taking vitamin D and simvastatin daily may reduce the number of migraines people who have episodic migraine get.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Migraine

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 years or older * Have had migraines for at least 3 years * Have between 4 and 15 migraines a month * Able to speak and read the English language Exclusion Criteria: * Women who are pregnant or nursing, or planning on becoming pregnant in the next 10 months * Individuals who have a had a heart attack, stroke, peripheral artery disease, atherosclerotic aortic disease, carotid artery disease, or diabetes * individuals at high risk for cardiovascular disease

Outcomes

Primary Outcomes

Migraine Frequency: Change From Baseline 12-week Period to Weeks 1 to 12

Time frame: Weeks 1 to 12

Migraine Frequency: Change From Baseline 12-week Period to Weeks 13 to 24

Time frame: Weeks 13 to 24