Treatment of Early Immunoglobulin A Nephropathy by Angiotensin Converting Enzyme Inhibitor - A Randomized Controlled Trial

Inclusion Criteria: * age between 18 and 65 * biopsy-confirmed IgA nephropathy * proteinuria less than 0.5 g per day, normal blood pressure, and serum creatinine below 120 umol/l * willingness to give written informed consent and willingness to participate in and comply with the study protocol Exclusion Criteria: * expected survival less than 2 years * pregnant or nursing mother, or women of childbearing potential without an effective method of birth control * history of myocardial infarction, congestive heart failure, or any other medical indication that necessitate the use of ACE inhibitor * evidence of clinically significant hepatic, gastrointestinal, autoimmune disease * history of malignancy, drug or alcohol abuse * participation in any previous trial on ACE inhibitor * taking other investigational drugs within the past 30 days * history of non-compliance to medical regimens and patients who are considered potentially unreliable * known history of sensitivity / allergy to ACE inhibitor