Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin

Inclusion Criteria: * Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age ≥ 65 years old, Diabetes requiring medication, Documented history of 2nd prior MI (\>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic, non-end stage renal dysfunction. * Females of child-bearing potential must have a negative pregnancy test at enrollment * Persons who are currently taking aspirin between 75 and 150 mg once daily Exclusion Criteria: * Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start * Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start * Persons with known bleeding disorders * Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin * Persons with a history of ischemic stroke * Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days. * Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker * Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery * Persons with known severe liver disease * Persons with kidney failure requiring dialysis * Persons with life expectancy \< 1 year