PNU-100480 In Newly Diagnosed, Drug Sensitive Patients With Pulmonary TB; Early Bactericidal Activity; Whole Blood Assay

Inclusion Criteria: * Adult males or females between 18 and 65 years; women of childbearing potential must be willing to adhere to lifestyle requirements regarding contraception/pregnancy prevention. * Newly diagnosed sputum smear-positive pulmonary TB confirmed with acid-fast bacillus (AFB) smear and chest x-ray. Patients with TB more than 5 years ago who completed treatment, are healthy, and meet other inclusion criteria may be included. * Body weight between 40 and 90 kg, inclusive (in light clothing, no shoes). * Reasonably normal hemoglobin (\>=8 gm/dL), renal function (serum creatinine \<2 mg/dL), hepatic function (serum AST \<3xULN and total bilirubin \<1.3 mg/dL), and random glucose \<150 mg/dL. Exclusion Criteria: * HIV infection with helper/inducer T-lymphocytes (CD4 cell) count of \<=350x10-6/L. * Presence of significant hemoptysis. Subjects who cough up frank blood (more than blood streaked sputum) will not be eligible. * Pregnant or nursing females; females of childbearing potential unwilling or unable to adhere to contraception guidelines. * Significant respiratory impairment (respiratory rate \>35/minute). * Clinical suspicion of disseminated TB or tuberculosis meningitis. * Subjects with diabetes mellitus on insulin and/or who have poorly controlled disease. * Subjects with confirmed or suspected multi-drug resistant TB.