Experimental and clinical studies in adults have reported that green tea catechins prevent influenza infection. In this clinical randomized study, the investigators aimed to determine the effects of gargling with green tea on the prophylaxis of influenza infection among high school teenagers.
Influenza infection is the principal cause of acute respiratory illnesses and occurs in epidemic or pandemic worldwide. It spreads easily among high school students and from them to the rest of the community; therefore the prevention of influenza is very important. Experimental studies have revealed that some components of green tea can prevent influenza infection in vitro. In clinically, gargling with green tea catechins has been reported to have possibilities to preventing influenza infection in adults; however, little clinical evidence in teenagers has so far been existed. Based on this background, the investigators designed a randomized study to evaluate the clinical efficacy of gargling with green tea in preventing influenza infection among high school students.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
640
Gargling three times daily for 90 days
University of Shizuoka
Shizuoka, Shizuoka, Japan
RECRUITINGthe incidence rates of influenza infection
Time frame: Until 3 months gargling
severity of influenza symptoms
Time frame: until 3 months gargling
influenza-free time during the study period
Time frame: until 3 months gargling
incidence of complications
Time frame: until 3 months gargling
incidence rates of upper respiratory tract infections
Time frame: until 3 months gargling
incidence of days of absence from school
Time frame: until 3 months gargling
occurrence of the adverse events
Time frame: until 3 months gargling
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