There is no difference in the rate and extent of absorption of the material sparing tablet (MST), the Phase2b/3 formulation (P2b/3) with sodium lauryl sulphate (SLS) and the p2b/3 formulation without SLS.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
18
oral, 6mg, single dose
oral, 6mg, single dose
oral, 6mg, single dose
Pfizer Investigational Site
Singapore, Singapore
Area under the plasma concentration-time profile from time zero extrapolated to infinite time (AUCinf)
Time frame: predose to day 7 of treatment period
Area under the plasma concentration-time profile from time zero to the time of the last quantifiable concentration (AUClast)
Time frame: predose to day 7 of treatment period
Maximum observed concentration within the dosing interval (Cmax)
Time frame: predose to day 7 of treatment period
Time for Cmax (Tmax)
Time frame: predose to day 7 of treatment period
Terminal half-life (t1/2)
Time frame: predose to day 7 of treatment period
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oral, 6mg, single dose
oral, 6mg, single dose
oral, 6mg, single dose
oral, 6mg, single dose
oral, 6mg, single dose
oral, 6mg, single dose
oral, 6mg, single dose
oral, 6mg, single dose
oral, 6mg, single dose