SYL040012. Tolerance and Effect on Intraocular Pressure in Subjects With Intraocular Pressure (IOP) >= 21 mm Hg

Inclusion Criteria: * Both genders. * \>/= 18 years of age with elevated IOP with OAG diagnosis. * Subjects must provide signed informed consent prior to participation in any study-related procedures * IOP \>/= 21 mmHg and \< 30 mmHg in three different assessment days. * Normal Ocular test (in both eyes): * Visual field: 24-2 or equivalent * Normal OCT * BCVA: \>/= 0,5 (20/40) Snellen scale, or \</=0.3 LogMar. * Normal Schirmer Test . * Normal funduscopy. Exclusion Criteria: * Pregnant or breastfeeding females or those with a positive pregnancy test. Females of childbearing potential who will not use a medically acceptable contraceptive method from selection and during the hole study. * Current relevant disease, including respiratory disease, cardiovascular, endocrine, neurological, hematological, renal, neoplastic, hepatopathy, gastrointestinal distress, hypertension or infectious acute processes. * Previous chronic processes or with rebound characteristics that could interfere with the study according to the investigator's judgment. * Having used betablockers and corticoids sporadically in the last 15 days whichever the route of administration. * Previous eye refractive surgery * Subjects with visual alteration with more than 3 dioptres for hypermetropy and/or astigmatism. * Use of contact lenses during the last 7 days before starting the treatment. * Subjects who has participated in a clinical trial during the past 2 months before study entry. * Analytic alterations medically relevant, at investigator judgment. * Positive results in test drug abuse during selection period. * Subjects with at least 2 visual fields or fiber layer measured in two different days abnormals * History of ocular infection or inflammation within the past 3 months * Pachymetry(in the middle of the cornea) \>600 microm or \< 500 microm. * Subjects with IOP associated to close angle glaucoma * History of chronic or severe acute ocular disease (i.e. scleritis, uveitis, blepharitis, conjunctivitis or herpes simplex virus) * History of intolerance to any of the components of the drug formulation * Subjects with previous iridotomy with IOP related with close angle glaucoma. * Previous ocular surgery in glaucoma * Corneal refractive surgery (e.g., keratotomy, PRK, LASIK, etc)