Adult Stem Cell Therapy for Repairing Articular Cartilage in Gonarthrosis

Inclusion Criteria: 1. Gonarthrosis grade II-III of Kellgren and Lawrence assessed by two observers 2. Chronic knee pain with mechanical characteristics 3. Absence of local or systemic septic process 4. Haematological and biochemical laboratory tests without significant alterations that contraindicate treatment. 5. Informed Consent form signed by the patient 6. The patient is able to understand the nature of the study Exclusion Criteria: 1. Patients \< 18 years or legally dependent 2. Patients \>65 years 3. Previous surgery of the knee 4. Intraarticular treatment in the past 6 month 5. Knee ligament or meniscus rupture observed by MRI 6. Any sign of infection 7. Positive serology for HIV-1 or HIV-2, Hepatitis B (HBsAg), Hepatitis C (Anti-HCV-Ab) and syphilis. 8. Congenital or acquired malformation resulting in significant deformity of the knee and leading to problems in application or evaluation of results. 9. Overweight expressed as body mass index (BMI) greater than 30.5 (obesity grade II). BMI estimated as mass (kg) / corporal surface (m2). 10. Pregnant women or intend to become pregnant or breast-feeding 11. Neoplasia 12. Immunosuppressive states 13. Participation in another clinical trial or treatment with a different investigational product within 30 days prior to inclusion in the study. 14. Other pathologic conditions or circumstances that difficult participation in the study according to medical criteria