Influence of Muscle Relaxation With Rocuronium Bromide During General Anaesthesia on Muscle Trauma and Postoperative Analgetic Consumption in Patients With Total Hip Prosthesis Implantation

Klinikum Hildesheim GmbH120 enrolled

Overview

The researchers want to investigate the effects of muscle relaxation with rocuronium bromide during general anaesthesia on muscle trauma (serum CK, CRP) and postoperative analgesic consumption in patients with total hip prosthesis replacement (general vs. spinal anaesthesia).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

120

Conditions

Muscle Relaxation Muscle Trauma Analgetic Consumption Total Hip Replacement

Interventions

Eligibility

Sex: ALLMin age: 55 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. patient agreement 2. indication for total hip replacement 3. age 55 - 80 years 4. weight 65 - 95 kg 5. first intervention 6. ASA classification I - III 7. general and spinal anaesthesia possible in this patient Exclusion Criteria: a) neuromuscular diseases b) surgery with muscle trauma (within the last 3 months) c) permanent immobility d) intramuscular injections (within the last 4 weeks) e) medication with opioids f) medication with co-analgetics g) contraindications for general or spinal anaesthesia h) dementia, cognitive dysfunction or sleep apnea \-

Outcomes

Primary Outcomes

degree of muscle trauma

serum CK and CRP levels are measured

Time frame: 24 hours

Secondary Outcomes

consumption of analgetics

consumption of piritramide is measured

Time frame: 3 days