Mesenchymal Stem Cell Transplantation in MS

Inclusion Criteria: 1. Inflammatory forms of MS 1. Relapsing-remitting MS (RRMS) patients 2. Secondary progressive MS (SPMS) patients with continued relapses 3. Primary progressive MS (PPMS) patients with enhancing MRI lesions and positive CSF (oligoclonal banding) 2. Age 18-50 years 3. Disease duration \>= 2 and \>= 10 years 4. EDSS 3.0 - 6.5 5. Progression, continued relapses or worsening MRI after at least a year of attempted therapy evidenced by: 1. Increase of \>= 1 EDSS point (if baseline EDSS \<= 5.0) or 0.5 EDSS points (if baseline EDSS \>= 5.5), or quantifiable, objective evidence of equivalent progression 2. \>= 1 moderate-severe relapses in past 18 months 3. \>= 1 Gadolinium enhancing lesions (double or triple dose Gadolinium) 4. \>= 1 new T2 lesion 5. For PPMS only, \>= 1 Gadolinium enhancing lesions 6. Has given informed consent to participate in the study. Exclusion Criteria: 1. SPMS without ongoing relapses 2. PPMS without positive CSF or Gadolinium enhancing lesions 3. \<= 3 months since treatment with any immunosuppressive therapy 4. \<=1 month since last treatment with interferon-B or glatiramer acetate 5. Corticosteroid treatment \<= 30 days 6. Relapse \<= 60 days 7. History of cancer or clinical or laboratory results indicative of severe systemic diseases, including infection for HIV, Hepatitis B or C 8. Any metallic or electronic device that precludes from undergoing MRI 9. Pregnancy or lactation 10. Current treatment with an investigational therapy