Observational Study to Assess Genotypes/Phenotypes Correlations in Type-2 Diabetic Retinopathy

Association for Innovation and Biomedical Research on Light and Image400 enrolled

Overview

The purpose of this study is to characterize type 2 diabetic patients with initial alterations of diabetic retinopathy (DR) based on 3 different phenotypes previously identified and different patterns of progression in order to correlate this data with genetic information.

This study aims to to characterize type 2 diabetic patients with initial alterations of diabetic retinopathy (DR) based on three different phenotypes previously identified and different patterns of progression \[Lobo, 2004\] in order to correlate this data with genetic information (based on a list of candidate genes previously identified as being involved in DR). The results of this study will be used exclusively for scientific purposes.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Type-2 Diabetic Retinopathy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Type-2 diabetic subjects form the PTDC/SAU-OSM/72635/2006 clinical trial (early stages of non-proliferative retinopathy - level 30 to 35 ETDRS;. females or males; age over 18 years) with a signed Informed Consent for this study. Exclusion Criteria: * Cataract or other eye disease that may interfere with fundus examinations; Vitreous syneresis or posterior vitreous detachment; and Dilatation of the pupil \< 5 mm.

Locations (1)

AIBILI - Clinical Trials Center

Coimbra, Coimbra District, Portugal

Outcomes

Primary Outcomes

Phenotypes of Diabetic Retinopathy progression.

Time frame: June 2011

Data from ClinicalTrials.gov

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