RNA Biomarkers in Tissue Samples From Infants With Acute Myeloid Leukemia

Children's Oncology Group20 enrolled

Overview

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in RNA and identify biomarkers related to cancer. PURPOSE: This research study is studying RNA biomarkers in tissue samples from infants with acute myeloid leukemia.

OBJECTIVES: * Sequence the microRNAs present in 20 infant AML samples as a pilot study. * Compare microRNAs present in infant AML samples to infant ALL samples that are being concurrently sequenced in a separate study to identify lineage- and translocation-specific microRNAs. OUTLINE: This is a multicenter study. Previously collected cryopreserved cells from diagnosis are sequenced using reverse transcriptase-PCR.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Leukemia

Interventions

RNA analysisGENETIC

nucleic acid sequencingGENETIC

reverse transcriptase-polymerase chain reactionGENETIC

laboratory biomarker analysisOTHER

Eligibility

Sex: ALLMax age: 1 Year

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Diagnosis of acute myeloid leukemia * Available cryopreserved cells from diagnosis PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Sequence of the microRNAs present in 20 infant acute myeloid leukemia (AML) samples

Comparison of microRNAs present in infant AML samples to infant acute lymphoblastic leukemia samples to identify lineage- and translocation-specific microRNAs

Data from ClinicalTrials.gov

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