The aim of this study is to evaluate the possible effects of daily intake of yogurt drink fortified with vitamin D alone or with vitamin D + calcium on some selected glycemic, metabolic, inflammatory and oxidative stress markers in patients with type 2 diabetes (T2DM).
ninety diabetic patients will be selected. Patients who are receiving vitamin D, calcium or omega-3 supplements within the last three months will be excluded. Patients will be assigned randomly to one of the three intervention groups. 1. Plain yogurt drink 2. Vitamin D-fortified yogurt drink 3. Vitamin D-calcium fortified yogurt drink. Each patient will consume 2 servings of yogurt drink every day for 3 months with lunch and dinner. At the first and last visits, dietary and laboratory assessments will be performed for all patients. Primary outcomes are improvement in glycemic, inflammatory and immunity markers and secondary outcome is prevention of long-term diabetic complications.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
90
daily intake of two bottle of plain yogurt drink
daily intake of two bottle of yogurt drink fortified with 500 IU vitamin D/250 mL
daily intake of two bottle of yogurt drink fortified with 500 IU vitamin D and 250 mg calcium/250 ml package
Serum 25-hydroxyvitamin D
Time frame: 12-week
Fasting Serum Glucose (FSG)
Time frame: 12-week
Insulin
fasting serum insulin concentration
Time frame: 12-week
Hemoglobin A1c (HbA1c)
Time frame: 12-week
Serum Triglyceride (TG)
Time frame: 12-week
Serum Total Cholesterol (Tchol)
Time frame: 12-week
Serum Low Density Lipoprotein (LDL)
Time frame: 12-week
Serum High Density Lipoprotein (HDL)
Time frame: 12-week
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