The purpose of this study is to evaluate the effect of intensive blood pressure control compared to standard blood pressure control on progression of coronary atherosclerosis by intravascular ultrasound in hypertensive patients with coronary artery disease.
Antihypertensive therapy is reported to reduce cardiovascular events in patients with coronary artery disease. The goal of blood pressure in patients with coronary artery disease is recommended to control below 140/90mmHg. However, the effect of intensive blood pressure control compared to standard blood pressure control is still unknown. The purpose of this study is to evaluate the effect of intensive blood pressure control compared to standard blood pressure control on progression of coronary atherosclerosis by intravascular ultrasound in hypertensive patients with coronary atherosclerosis after 18 months. The goal of systolic blood pressure is under 120mmHg in intensive blood pressure control group and under 140mmHg in standard blood pressure control group. The design of this study is randomized control study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
8
use losartan to control blood pressure
use losartan to control blood pressure
Division of Cardiology, Kyoto University Hospital
Kyoto, Kyoto, Japan
change of percent atheroma volume
change of percent atheroma volume measured by intravascular ultrasound
Time frame: 1.5-year
all cause death
Death from any cause
Time frame: 1.5-year
cardiac death
Death from cardiac diseases
Time frame: 1.5-year
cardiovascular death
Death from cardiovascular diseases
Time frame: 1.5-year
myocardial infarction
myocardial infarction defined by ARC
Time frame: 1.5-year
stroke
both ischemic and hemorrhagic strokes excluding transient ischemic attack
Time frame: 1.5-year
target-lesion revascularization
target-lesion revascularization
Time frame: 1.5-year
any coronary revascularization
any coronary revascularization
Time frame: 1.5-year
hospitalization due to angina pectoris
hospitalization due to angina pectoris
Time frame: 1.5-year
hospitalization due to heart failure
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
hospitalization due to heart failure
Time frame: 1.5-year
change of total atheroma volume
change of total atheroma volume measured by intravascular ultrasond
Time frame: 1.5-year
percent change of total atheroma volume
percent change of total atheroma volume measured by intravascular ultrasound
Time frame: 1.5-year
change of atheroma volume at most severe 10mm lesion
change of atheroma volume at most severe 10mm lesion measured by intravascular ultrasound
Time frame: 1.5-year