Effect of Wheat Dextrin on Calcium and Magnesium Absorption

Phase 4CompletedNCT01230840

Creighton University40 enrolled

Overview

To compare calcium and magnesium absorption within subjects with and without chronic consumption of wheat dextrin.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Colonic Inertia

Interventions

wheat dextrinDIETARY_SUPPLEMENT

5 grams of wheat dextrin baked in cookies will be taken 3 times a day for 2 weeks

placeboDIETARY_SUPPLEMENT

cookies not containing wheat dextrin will be taken 3 times a day for 2 weeks

Eligibility

Sex: FEMALEMin age: 19 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: \- Subjects will be generally healthy Caucasian females aged 19 and older with no known abnormalities of gastrointestinal function, and taking no medications that might alter absorptive performance. BMI will be between 19 and 31 kg/m2 \-

Outcomes

Primary Outcomes

Calcium Absorption

The calcium load to be tested will be 300 mg calcium from calcium and vitamin D fortified TropicanaTM orange juice extrinsically labeled with ≈3-7 μCi of 45Ca. The labeled orange juice will be ingested as part of a light meal, served as breakfast, after an overnight fast.

Time frame: within 2-4 weeks

Secondary Outcomes

Magnesium absorption

The magnesium load to be tested will be from calcium and vitamin D fortified TropicanaTM orange juice extrinsically labeled with 30 mg 26Mg. The labeled orange juice will be ingested as part of a light meal, served as breakfast, after an overnight fast.

Time frame: within 2-4 weeks

Data from ClinicalTrials.gov

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