Effect of Ageing on Airway Remodeling

University Hospital, Montpellier101 enrolled

Overview

The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.

Chest multidetector CT without injection and spirometry data will be obtained from a multicentric sample of individuals between 60 and 95 years of ageExclusion criteria were current smoking, history of smoking within the past 10 years, any known chronic or acute pulmonary disease. Individuals treated with Amiodarone, Bleomycin or methotrexate were excludedOutcome

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

101

Conditions

Aging

Interventions

EFR and TDMOTHER

EFR : Pulmonary function test TDM : tomodensitometry

Eligibility

Sex: ALLMin age: 60 YearsMax age: 95 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * People from 60 to 95 years old free from chest disease or history of chest disease Exclusion Criteria: * Chronic cough * Dyspnea * Sinonasal or chest infection during enrollment * Myocardial infarction. * Current smoker or past smoker with more than 10 pack year intoxication

Locations (1)

University Montpellier Hospital

Montpellier, France

Outcomes

Primary Outcomes

Bronchial wall thickness

Bronchial wall thickness and remodeling associated with aging

Time frame: 1 day

Data from ClinicalTrials.gov

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