The investigators want to know the role of Peripheral hematopoietic stem cell infusion in avoiding Drug Induced Liver Injury,and also try to research SNPs genotyping associated with Drug Induced Liver Injury.
1. The researcher investigate the incidence and the cause of Drug Induced Liver Injury in MBC. 2. Patients having a complete clinical history and physical examination, receive routine chemotherapy. 3. Venous blood Sample(4 ml)is collected before and after each cycle according to the planning time. 4. Genomic DNA,RNA and upper serum is isolated. ELISA、rt-PCR or PCR-direct sequencing is used to detect the protein or gene expression associated with liver function.
Study Type
OBSERVATIONAL
Enrollment
52
Beijing Cancer Hospital
Beijing, China
Protective effection of peripheral hematopoietic stem cell infusion for DILI
Patients receiving PHSC infusion after chemotherapy will have lower incidence of DILI. PHSC infusion may improve the liver function.
Time frame: 3 months
SNPs genotyping associated with Drug Induced Liver Injury
Some SNPs will be find to associated with DILI.
Time frame: 3 months
Change of cytokines
Changes of cytokines in periphral blood related with liver function with be observed.
Time frame: 3 months
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