This is a research study to determine if giving acetaminophen intravenously in hte operating room will decrease the number of patients who require additional pain medicine, such as morphine, after surgery in the recovery room.
Primary Specific Aim: To determine if adding an intraoperative dose of intravenous acetaminphen to usual and customary analgesics during ambulatory surgery impacts the proportion of patients remaining opioid-free in the post-anesthesia recovery room. Hypothesis: Adding an intraoperative dose of intravenous acetaminophen to usual and customary analgesics during ambulatory surgery increases the proportion of patients remaining opioid-free in the post-anesthesia recovery room. Secondary Specific Aim: To determine if adding an intraoperative dose of intravenous acetaminophen to usual and customary analgesics during amublatory surgery impacts the required doses of additional perioperative analgesics. Hypothesis: Adding an intraoperative dose of intravenous acetaminophen to usual and customary analgesics during ambulatory surgery decreases the required doses of additional analgesics in both the operating room and post-anesthesia recovery room.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Acetaminophen 1000 mg administered over 15 minutes intravenously as soon as feasible intraoperatively.
Normal saline administered over 15 minutes intravenously as soon as feasible intraoperatively.
UCSD Medical Center (Hillcrest and Thornton)
San Diego, California, United States
The primary endpoint is the difference in proportions of patients from each treatment group who avoid using any opioids following anesthesia emergence until recovery room discharge.
Time frame: Day of Surgery
A secondary endpoint for this investigation will be the total dose of fentanyl administered to the patient.
Time frame: Day of Surgery
A secondary outcome for this investigation will be the total dose of morphine administered to the patient.
Time frame: Day of Surgery
A secondary outcome for this investigation will be the total dose of ibuprophen administered to the patient.
Time frame: Day of Surgery
A secondary outcome measure for this investigation will be the total dose of oxycodone administered to the patient.
Time frame: Day of Surgery
A secondary outcome measure will be any surgeon-administered local anesthetics used for wound infiltration.
Time frame: Day of Surgery
A secondary outcome measure for this study will be any recovery-room anti-emetics administered to the patient.
Time frame: Day of Surgery
Patients will be asked at time of PACU discharge, "Overall, how would you rate the study treatments?" Responses will be on 0 to 3 scale where 0=poor and 3=excellent.
Time frame: Day of Surgery
Patients will be asked at time of PACU discharge, "Overall, how would you rate the level of pain relief from study medication?" Responses will be on 0 to 3 scale where 0=poor and 3=excellent.
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Time frame: Day of Surgery
Adverse events
Time frame: Up to one year postoperative