Does Valproate Increase Levels of Folate Receptor Autoantibodies in Women?

Northwell Health38 enrolled

Overview

Women who take folate (folic acid) before getting pregnant can lower the risk of giving birth to infant with certain birth defects. However, some medications may affect the action of folate. The purpose of this study is to compare the effect of two anti-epileptic drugs on how folate works in our body.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Epilepsy Psychiatric or Mood Diseases or Conditions

Interventions

No interventionOTHER

No intervention. This is a cross-sectional study.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women ages 18-50 years inclusive who are taking valproate or lamotrigine for neurologic or psychiatric conditions * Valproate of lamotrigine must be used as monotherapy at stable doses for 6 weeks prior to the study for the neurologic or psychiatric illness; medications taken for other reasons are not excluded. Exclusion Criteria: * Women with prior exposure to valproate or lamotrigine if they are taking lamotrigine or valproate respectively.

Locations (1)

North Shore Long Island Jewish Health System

Great Neck, New York, United States

Outcomes

Primary Outcomes

Levels of Folate Receptor Autoantibodies

ELISA assays using immobilized folate receptor protein were performed to determine the titers of immunoglobulin G, immunoglobulin M, and combined immunoglobulin G and immunoglobulin M to folate receptor in serum samples collected from both groups of women.

Time frame: On the same day after informed consent was obtained

Data from ClinicalTrials.gov

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